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KMID : 0383819580050010066
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Tuberculosis and Respiratory Diseases
1958 Volume.5 No. 1 p.66 ~ p.71
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Tuberculin Allergy and Immunity After the Inoculation of Antituberculous-Drug-Resistant B.C.G.
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이성관(李性寬)/Sung Kwan Lee
김경수(金炅守)/Kyung Soo Kim
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Abstract
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Although it is well known that the B.C.G. inoculation plays an important role in the
prevention of tuberculosis, many cases may be infected by the virulent tuberculous
bacilli before the B.C.G. inoculation in the area where active cases are prevalent, like in
Korea. Thus, in our laboratory I.N.A.H-and streptomycin -esistant B.C.G. was cultured
in vitro and it was inoculated in rabbits. I.N.A.H. and streptomycin were administered to
these rabbits simultaneously and the B.C.G. local lesion and tuberculin-allergy were
observed.
1) When the B.C.G. which is rosistant to 50r of I.N.A.H. and B.C.G. resistant to 50r
of Streptomycin were compared with non-resistant Control B.C.G. ocal lesion and
tuberculin allergy, but the development of tuberculin allergy was delayed in the resistant
group.
2) After the inoculation of control B.C.G., the untreated group was compared with the
groups treated by I.N.A.H. and Streptomycin respectively. There were no differences
between the I.N.A.H. treated groups and the untreated group, but in the Streptomycin
treated group the local lesion and tuberculin allergy were significantly weak.
3) After the inoculation of B.C.G. which is resistant to 50r of I.N.A.H., there were no
differences between the untreated group and I.N.A.H treated (5㎎ per kg of body
weight) group.
4) After the inoculation of B.C.G. which is resistant to 50r of Streptomycin treated(10
㎎ per ㎏ of body weight) group than the untreated group.
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